منابع مشابه
Studies of Liver Function. Benzoate Administration and Hippuric Acid Synthesis
Much work has been done in an effort to understand the complex function of the liver and considerable information of value has been obtained. It is fair to say, however, that the estimation of functional capacity of the liver cannot as yet be made with any convincing accuracy. We have reason to believe that the liver has a very large factor of safety-that it can tolerate an extensive injury and...
متن کاملStudies in the Synthesis of Hippuric Acid in the Animal Organism. Ii. the Synthesis and Rate of Elimination of Hippuric Acid after Benzoate
The question of the extent of the ability of the human organism to detoxicate benzoic acid by conjugation with glycocoll and elimination as hippuric acid in the urine has frequently been raised. Lewinsk? observed in the urine of men to whom 12 to 20 grams of benzoic acid had been given in small doses during t,he course of twelve hours, neither free benzoic acid nor benzoyl glycuronates. With la...
متن کاملUnidimensional Thin Layer Chromatography of Salicylic Acid Derivatives on Boric Acid-Impregnated Plates in Drugs Studies
A unidimensional Thin Layer Chromatography system for the separation of salicylic acid and its derivatives (sulfosalicylic acid and Aspirin) has been developed. The separation was successfully using a solvent system of chloroform-methanol-water-ammonium hydroxide 120:75:6:2 (V/V) as mobile phase on TLC plates impregnated with boric acid. The method is based on different behavior of investigated...
متن کاملColorimetric method for hippuric acid.
FTIPPURIC ACID 1S an important metabolic product normally present in urine in amounts determined by tile ingestion of benzyl-containing foods and medicinals (ii). Because this compound is comparatively inert chemically, identification requires isolation and the determination of physical constants after extensive purification. There has long been need for a reliable and sensitive color reaction ...
متن کاملStudies on the Synthesis of Hippuric Acid in the Animal Organism
The source of the glycocoll made available for detoxication after the ingestion of benzoic acid or its salts is not known. The possibility that hippuric acid is formed from the glycocoll secreted as glycocholic acid in the bile either in the intestine or in the circulatory system has been suggested. Such a theory would ascribe to the bile an important function. Little experimental evidence in s...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1952
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.72.9_1160